trophoblast stem cellsThe extra embryonic equivalent of ESCs, TSCs give rise to all cell types within the placenta. We study how oxygen tension and metabolism regulate TSC fate via HIF-dependent transcription. We are applying these insights to understand the causes of preeclampsia.
|
dormancyMetabolic dormancy is a little understood mechanism to combat oxygen/glucose deprivation. We discovered how a HIF-target gene, HIGD1A, regulate this process, and are studying its effects on tumor dormancy and neural responses to stroke.
|
placental metabolismThe placenta consumes 40-60% of the oxygen and glucose delivered to it at term, despite the fact that it comprises only 10-20% of the mass of the conceptus. We study how alterations in placental metabolism affect its development and impact nutrient transport to the fetus.
|